Microfluidics: From crystallization to serial time-resolved crystallography | Zendy

Shuo Sui | Zendy; Sarah L. Perry | Zendy

AI Assistant Blog Pricing

Home ZAIA Blog

Open Access

Microfluidics: From crystallization to serial time-resolved crystallography

Author(s) -

Shuo Sui,

Sarah L. Perry

Publication year - 2017

Publication title -

structural dynamics

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 1.415

H-Index - 29

ISSN - 2329-7778

DOI - 10.1063/1.4979640

Subject(s) - microfluidics , protein crystallization , crystallization , diffraction , protein detection , molecular biophysics , computer science , structural biology , protein structure , biological system , nanotechnology , crystallography , computational biology , chemistry , materials science , biology , physics , biochemistry , optics , organic chemistry

Capturing protein structural dynamics in real-time has tremendous potential in elucidating biological functions and providing information for structure-based drug design. While time-resolved structure determination has long been considered inaccessible for a vast majority of protein targets, serial methods for crystallography have remarkable potential in facilitating such analyses. Here, we review the impact of microfluidic technologies on protein crystal growth and X-ray diffraction analysis. In particular, we focus on applications of microfluidics for use in serial crystallography experiments for the time-resolved determination of protein structural dynamics

The content you want is available to Zendy users.

Already have an account? Click here to sign in.

Having issues? You can contact us here

Accelerating Research