A multimodal instrument for real-time in situ study of ultrasound and cavitation mediated drug delivery | Zendy

Shuning Bian | Zendy; Anjali Seth | Zendy; Dan Daly | Zendy; Robert Carlisle | Zendy; Eleanor Stride | Zendy

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A multimodal instrument for real-time in situ study of ultrasound and cavitation mediated drug delivery

Author(s) -

Shuning Bian,

Anjali Seth,

Dan Daly,

Robert Carlisle,

Eleanor Stride

Publication year - 2017

Publication title -

review of scientific instruments

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 0.605

H-Index - 165

eISSN - 1089-7623

pISSN - 0034-6748

DOI - 10.1063/1.4978811

Subject(s) - cavitation , ultrasound , drug delivery , in situ , medical physics , computer science , measuring instrument , biomedical engineering , materials science , acoustics , nanotechnology , medicine , physics , thermodynamics , meteorology

The development of a multimodal instrument capable of real-time in situ measurements of cavitation activity and effect in tissue mimicking phantoms during ultrasound and cavitation mediated drug delivery experiments is described here. The instrument features an acoustic arm that can expose phantoms to high-intensity focused-ultrasound while measuring cavitation activity and an optical arm that monitors cavitation effect using confocal microscopy. This combination of modalities allows real-time in situ characterisation of drug delivery in tissue and tissue mimicking phantoms during ultrasound and cavitation mediated drug delivery experiments. A representative result, obtained with a tissue mimicking phantom and acoustically activated droplets, is presented here as a demonstration of the instrument’s capabilities and potential applications

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