Open AccessElectrical trapping mechanism of single-microparticles in a pore sensor
Author(s) -
Akihide Arima,
Makusu Tsutsui,
Yuhui He,
Sou Ryuzaki,
Masateru Taniguchi
Publication year - 2016
Publication title -
aip advances
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.421
H-Index - 58
ISSN - 2158-3226
DOI - 10.1063/1.4967214
Subject(s) - nanopore , microchannel , trapping , particle (ecology) , conductance , electrophoresis , materials science , nanotechnology , resistive touchscreen , ionic bonding , current (fluid) , nanoscopic scale , membrane , chemical physics , ion current , optoelectronics , chemistry , ion , chromatography , ecology , biochemistry , oceanography , engineering , organic chemistry , geology , electrical engineering , biology , mathematics , combinatorics
Nanopore sensing via resistive pulse technique are utilized as a potent tool to characterize physical and chemical property of single –molecules and –particles. In this article, we studied the influence of particle trajectory to the ionic conductance through a pore. We performed the optical/electrical simultaneous sensing of electrophoretic capture dynamics of single-particles at a pore using a microchannel/nanopore system. We detected ionic current drops synchronous to a fluorescently dyed particle being electrophoretically drawn and become immobilized at a pore in the optical imaging. We also identified anomalous trapping events wherein particles were captured at nanoscale pin-holes formed unintentionally in a SiN membrane that gave rise to relatively small current drops. This method is expected to be a useful platform for testing novel nanopore sensor design wherein current behaves in unpredictable manner
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