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Temporal Airy pulses control cell poration
Author(s) -
Sébastien Courvoisier,
Nadine Götte,
Bastian Zielinski,
Thomas Winkler,
Cristian Sarpe,
Arne Senftleben,
Luigi Bonacina,
JeanPierre Wolf,
T. Baumert
Publication year - 2016
Publication title -
apl photonics
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 2.094
H-Index - 34
ISSN - 2378-0967
DOI - 10.1063/1.4948367
Subject(s) - optics , laser , materials science , bandwidth (computing) , pulse (music) , intensity (physics) , dispersion (optics) , phase (matter) , physics , telecommunications , computer science , quantum mechanics , detector
We show that spectral phase shaping of fs-laser pulses can be used to optimize laser-cell membrane interactions in water environment. The energy and peak intensity thresholds required for cell poration with single pulse in the nJ range can be significantly reduced (25% reduction in energy and 88% reduction in peak intensity) by using temporal Airy pulses, controlled by positive third order dispersion, as compared to bandwidth limited pulses. Temporal Airy pulses are also effective to control the morphology of the induced pores, with prospective applications from cellular to tissue opto-surgery and transfection

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