Conducting polymer functionalized single-walled carbon nanotube based chemiresistive biosensor for the detection of human cardiac myoglobin | Zendy

Nidhi Puri | Zendy; Asad Niazi | Zendy; Ashók M. Biradar | Zendy; Ashok Mulchandani | Zendy; Rajesh Rajesh | Zendy

Open Access

Conducting polymer functionalized single-walled carbon nanotube based chemiresistive biosensor for the detection of human cardiac myoglobin

Author(s) -

Nidhi Puri,

Asad Niazi,

Ashók M. Biradar,

Ashok Mulchandani,

Rajesh Rajesh

Publication year - 2014

Publication title -

applied physics letters

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 1.182

H-Index - 442

eISSN - 1077-3118

pISSN - 0003-6951

DOI - 10.1063/1.4897972

Subject(s) - myoglobin , carbon nanotube , biosensor , materials science , linker , nanotechnology , nanosensor , polymer , conductive polymer , conductance , fabrication , chemistry , organic chemistry , mathematics , combinatorics , computer science , composite material , operating system , medicine , alternative medicine , pathology

We report the fabrication of a single-walled carbon nanotube (SWNT) based ultrasensitive label-free chemiresistive biosensor for the detection of human cardiac biomarker, myoglobin (Ag-cMb). Poly(pyrrole-co-pyrrolepropylic acid) with pendant carboxyl groups was electrochemically deposited on electrophoretically aligned SWNT channel, as a conducting linker, for biomolecular immobilization of highly specific cardiac myoglobin antibody. The device was characterized by scanning electron microscopy, source-drain current-voltage (I-V), and charge-transfer characteristic studies. The device exhibited a linear response with a change in conductance in SWNT channel towards the target, Ag-cMb, over the concentration range of 1.0 to 1000 ng ml−1 with a sensitivity of ∼118% per decade with high specificity.

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