Continuous-time control of alternans in long Purkinje fibers | Zendy

Alejandro Garzón | Zendy; Roman O. Grigoriev | Zendy; Flavio H. Fenton | Zendy

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Continuous-time control of alternans in long Purkinje fibers

Author(s) -

Alejandro Garzón,

Roman O. Grigoriev,

Flavio H. Fenton

Publication year - 2014

Publication title -

chaos an interdisciplinary journal of nonlinear science

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 0.971

H-Index - 113

eISSN - 1089-7682

pISSN - 1054-1500

DOI - 10.1063/1.4893295

Subject(s) - purkinje fibers , fibrillation , interval (graph theory) , control theory (sociology) , feedback control , ventricular fibrillation , computer science , control (management) , cardiology , medicine , mathematics , atrial fibrillation , engineering , electrophysiology , control engineering , artificial intelligence , combinatorics

Alternans-an arrhythmic response of cardiac tissue to periodic pacing-often serves as a precursor to a more dangerous, and potentially lethal, state of fibrillation. Suppression of alternans using feedback control may be a plausible method to prevent fibrillation. Several approaches based on impulsive control have been proposed previously, where feedback is applied for a brief instance of time during each pacing interval. This paper presents a continuous-time approach, where feedback current is applied at all times, which is capable of suppressing alternans in fibers of significantly greater length (up to at least 4 cm), compared with impulsive control (less than 1 cm), and for a wide range of pacing cycle lengths.

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