Piezoresistive measurement of Swine H1N1 Hemagglutinin peptide binding with microcantilever arrays | Zendy

Nadia M. Bajwa | Zendy; C. J. Maldonado | Zendy; Thomas Thundat | Zendy; Ali Passian | Zendy

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Piezoresistive measurement of Swine H1N1 Hemagglutinin peptide binding with microcantilever arrays

Author(s) -

Nadia M. Bajwa,

C. J. Maldonado,

Thomas Thundat,

Ali Passian

Publication year - 2014

Publication title -

aip advances

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 0.421

H-Index - 58

ISSN - 2158-3226

DOI - 10.1063/1.4869636

Subject(s) - hemagglutinin (influenza) , piezoresistive effect , peptide , virus , influenza a virus , transduction (biophysics) , biophysics , nanotechnology , virology , microbiology and biotechnology , chemistry , biology , materials science , biochemistry , optoelectronics

Effective detection of Swine H1N1 Hemagglutinin peptide is crucial as it could be used as a positive control to screen for highly infectious flu strains such as Swine-Origin Influenza A (H1N1). Piezoresistive microcantilever arrays present a pathway towards highly sensitive and label-free detection of biomolecules by transducing the antigen-antibody binding into change in resistivity via induced surface stress variation. We demonstrate a mechanical transduction of Swine H1N1 Hemagglutinin peptide binding and suggest the employed technique may offer a potential platform for detection of the H1N1 virus, which could be clinically used to diagnose and provide subsequent relief

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