Degeneration of amyloid-ß fibrils caused by exposure to low-temperature atmospheric-pressure plasma in aqueous solution | Zendy

Eisuke Takai | Zendy; Gai Ohashi | Zendy; Tomonori Yoshida | Zendy; Karin Sörgjerd | Zendy; Tamotsu Zako | Zendy; Mizuo Maeda | Zendy; Katsuhisa Kitano | Zendy; Kentaro Shiraki | Zendy

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Degeneration of amyloid-ß fibrils caused by exposure to low-temperature atmospheric-pressure plasma in aqueous solution

Author(s) -

Eisuke Takai,

Gai Ohashi,

Tomonori Yoshida,

Karin Sörgjerd,

Tamotsu Zako,

Mizuo Maeda,

Katsuhisa Kitano,

Kentaro Shiraki

Publication year - 2014

Publication title -

applied physics letters

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 1.182

H-Index - 442

eISSN - 1077-3118

pISSN - 0003-6951

DOI - 10.1063/1.4861842

Subject(s) - senile plaques , atmospheric pressure plasma , fibril , chemistry , aqueous solution , amyloid fibril , biophysics , atmospheric pressure , proteolysis , amyloid (mycology) , plasma , alzheimer's disease , amyloid β , pathology , biochemistry , organic chemistry , inorganic chemistry , disease , biology , medicine , physics , quantum mechanics , oceanography , enzyme , geology

Low-temperature atmospheric-pressure plasma was applied to degenerate amyloid-ß (Aß) fibrils, which are a major component of neuritic plaque associated with Alzheimer\u27s disease (AD). We showed that an Aß fibril exposed to a low-frequency (LF) plasma jet in aqueous solution retained its morphology, molecular weight, and cytotoxicity, but, intriguingly, decreased in protease resistance and ß-sheet content. These results suggested that an LF plasma jet could be utilized for the treatment of AD to eliminate neuritic plaque by accelerating the proteolysis of Aß fibrils

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