Mechanism of aluminium bio-mineralization in the apoferritin cavity | Zendy

Michela Chiarpotto | Zendy; Gabriele Ciasca | Zendy; Massimo Vassalli | Zendy; Cristina Rossi | Zendy; Gaetano Campi | Zendy; Antonella Ricci | Zendy; Beatrice Bocca | Zendy; Anna Pino | Zendy; Alessandro Alimonti | Zendy; Pasquale De Sole | Zendy; Massimiliano Papi | Zendy

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Mechanism of aluminium bio-mineralization in the apoferritin cavity

Author(s) -

Michela Chiarpotto,

Gabriele Ciasca,

Massimo Vassalli,

Cristina Rossi,

Gaetano Campi,

Antonella Ricci,

Beatrice Bocca,

Anna Pino,

Alessandro Alimonti,

Pasquale De Sole,

Massimiliano Papi

Publication year - 2013

Publication title -

applied physics letters

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 1.182

H-Index - 442

eISSN - 1077-3118

pISSN - 0003-6951

DOI - 10.1063/1.4818749

Subject(s) - aluminium , ferritin , ionic bonding , mineralization (soil science) , chemistry , inorganic chemistry , crystallography , biophysics , ion , biochemistry , biology , organic chemistry , nitrogen

Many experimental evidences point out the correlation between the presence of aluminum-ferritin\udcomplex and neursopathological disorders. In these complexes, two different ranges of Aluminium\ud(Al) atoms are usually found, i.e., just few atoms or several hundreds. Here, we investigated the invitro\udAl-apoferritin binding, with the aim to elucidate the mechanism behind the formation of Alferritin\udcomplexes in-vivo. To this purpose, we studied the mineralization of Al in its ionic and\udcomplexed form with citrate demonstrating that high Al levels found in clinical studies can be\udobtained only conveying Al by small physiological ligands

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