A peristaltic pump driven [sup 89]Zr separation module | Zendy

Jonathan Siikanen | Zendy; Mikael Peterson | Zendy; Thuy Tran | Zendy; Per Roos | Zendy; Tomas Ohlsson | Zendy; A. Sandell | Zendy

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A peristaltic pump driven [sup 89]Zr separation module

Author(s) -

Jonathan Siikanen,

Mikael Peterson,

Thuy Tran,

Per Roos,

Tomas Ohlsson,

A. Sandell

Publication year - 2012

Publication title -

aip conference proceedings

Language(s) - English

Resource type - Conference proceedings

SCImago Journal Rank - 0.177

H-Index - 75

eISSN - 1551-7616

pISSN - 0094-243X

DOI - 10.1063/1.4773969

Subject(s) - peristaltic pump , yttrium , monoclonal antibody , vial , dissolution , fragment (logic) , separation (statistics) , chromatography , chemistry , materials science , computer science , antibody , physics , algorithm , organic chemistry , machine learning , meteorology , immunology , biology , oxide

To facilitate the separation of Zr-89 produced in yttrium foils, an automated separation module was designed and assembled. The module separates more than 85% of produced Zr-89 - activity in 3 g foils in less than 90 min. About 10 % remains in the dissolving vial. The quality of the separated Zr-89 activity was investigated for labeling of the HER2-binding monoclonal antibody fragment, trastuzumab-Fab

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