Routine production of copper-64 using 11.7MeV protons | Zendy

Charmaine M. Jeffery | Zendy; Suzanne V. Smith | Zendy; Ali Asad | Zendy; S. Chan | Zendy; Roger I. Price | Zendy

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Routine production of copper-64 using 11.7MeV protons

Author(s) -

Charmaine M. Jeffery,

Suzanne V. Smith,

Ali Asad,

S. Chan,

Roger I. Price

Publication year - 2012

Publication title -

aip conference proceedings

Language(s) - English

Resource type - Conference proceedings

SCImago Journal Rank - 0.177

H-Index - 75

eISSN - 1551-7616

pISSN - 0094-243X

DOI - 10.1063/1.4773946

Subject(s) - copper , nickel , radiochemistry , irradiation , nuclear chemistry , ion exchange , elution , cobalt , titration , isotope , chemistry , ion , electroplating , analytical chemistry (journal) , materials science , inorganic chemistry , metallurgy , chromatography , physics , organic chemistry , quantum mechanics , layer (electronics) , nuclear physics

Reliable production of copper-64 (64Cu) was achieved by irradiating enriched nickel-64 (64Ni, >94.8%) in an IBA 18/9 cyclotron. Nickel-64 (19.1 ± 3.0 mg) was electroplated onto an Au disc (125μm × 15mm). Targets were irradiated with 11.7 MeV protons for 2 hours at 40μA. Copper isotopes (60,61,62,64Cu) were separated from target nickel and cobalt isotopes (55,57,61Co) using a single ion exchange column, eluted with varying concentration of low HCl alcohol solutions. The 64Ni target material was recovered and reused. The 64Cu production rate was 1.46±0.3MBq/μA.hr/mg64Ni(n = 10) (with a maximum of 2.6GBq of 64Cu isolated after 2hr irradiation at 40uA. Radionuclidic purity of the 64Cu was 98.7 ± 1.6 % at end of separation. Cu content was < 6mg/L (n = 21). The specific activity of 64Cu was determined by ICP-MS and by titration with Diamsar to be 28.9±13.0GBq/μmol[0.70±0.35Ci/μmol]/(μA.hr/mg64Ni)(n = 10) and 13.1±12.0GBq/μmol[0.35±0.32Ci/μmol]/(μA.hr/mg64Ni)(n = 9), respectively; which are in agreement, however...

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