Deformation measurement of individual cells in large populations using a single-cell microchamber array chip | Zendy

Il Doh | Zendy; Won Chul Lee | Zendy; Y.-H. Cho | Zendy; Albert P. Pisano | Zendy; Frans A. Kuypers | Zendy

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Deformation measurement of individual cells in large populations using a single-cell microchamber array chip

Author(s) -

Il Doh,

Won Chul Lee,

Y.-H. Cho,

Albert P. Pisano,

Frans A. Kuypers

Publication year - 2012

Publication title -

applied physics letters

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 1.182

H-Index - 442

eISSN - 1077-3118

pISSN - 0003-6951

DOI - 10.1063/1.4704923

Subject(s) - deformation (meteorology) , biological system , electrode , measure (data warehouse) , cell , materials science , nanotechnology , chemistry , computer science , biology , composite material , biochemistry , database

We analyze the deformability of individual red blood cells (RBCs) using SiCMA technology. Our approach is adequate to quickly measure large numbers of individual cells in heterogeneous populations. Individual cells are trapped in a large-scale array of micro-wells, and dielectrophoretic (DEP) force is applied to deform the cells. The simple structures of micro-wells and DEP electrodes facilitate the analysis of thousands of RBCs in parallel. This unique method allows the correlation of red cell deformation with cell surface and cytosolic characteristics to define the distribution of individual cellular characteristics in heterogeneous populations.

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