Biological effectiveness on live cells of laser driven protons at dose rates exceeding 109Gy/s | Zendy

D. Doria | Zendy; K. F. Kakolee | Zendy; S. Kar | Zendy; S. K. Litt | Zendy; F. Fiorini | Zendy; H. Ahmed | Zendy; S. Green | Zendy; J. Charles G. Jeynes | Zendy; Joy N. Kavanagh | Zendy; D. Kirby | Zendy; K.J. Kirkby | Zendy; C. L. S. Lewis | Zendy; Michael J. Merchant | Zendy; G. Nersisyan | Zendy; R. Prasad | Zendy; Kevin M. Prise | Zendy; Giuseppe Schettino | Zendy; M. Zepf | Zendy; M. Borghesi | Zendy

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Biological effectiveness on live cells of laser driven protons at dose rates exceeding 10⁹Gy/s

Author(s) -

D. Doria,

K. F. Kakolee,

S. Kar,

S. K. Litt,

F. Fiorini,

H. Ahmed,

S. Green,

J. Charles G. Jeynes,

Joy N. Kavanagh,

D. Kirby,

K.J. Kirkby,

C. L. S. Lewis,

Michael J. Merchant,

G. Nersisyan,

R. Prasad,

Kevin M. Prise,

Giuseppe Schettino,

M. Zepf,

M. Borghesi

Publication year - 2012

Publication title -

aip advances

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 0.421

H-Index - 58

ISSN - 2158-3226

DOI - 10.1063/1.3699063

Subject(s) - relative biological effectiveness , proton , irradiation , laser , clonogenic assay , dose rate , radiochemistry , radiobiology , chemistry , nuclear medicine , optics , physics , nuclear physics , medicine , in vitro , biochemistry

The ultrashort duration of laser-driven multi-MeV ion bursts offers the possibility of radiobiological studies at extremely high dose rates. Employing the TARANIS Terawatt laser at Queen's University, the effect of proton irradiation at MeV-range energies on live cells has been investigated at dose rates exceeding 109 Gy/s as a single exposure. A clonogenic assay showed consistent lethal effects on V-79 live cells, which, even at these dose rates, appear to be in line with previously published results employing conventional sources. A Relative Biological Effectiveness (RBE) of 1.4±0.2 at 10% survival is estimated from a comparison with a 225 kVp X-ray source.

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