Feasibility of noninvasive cavitation-guided blood-brain barrier opening using focused ultrasound and microbubbles in nonhuman primates | Zendy

YaoSheng Tung | Zendy; Fabrice Marquet | Zendy; Tobias Teichert | Zendy; Vincent P. Ferrera | Zendy; Elisa E. Konofagou | Zendy

Open Access

Feasibility of noninvasive cavitation-guided blood-brain barrier opening using focused ultrasound and microbubbles in nonhuman primates

Author(s) -

YaoSheng Tung,

Fabrice Marquet,

Tobias Teichert,

Vincent P. Ferrera,

Elisa E. Konofagou

Publication year - 2011

Publication title -

applied physics letters

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 1.182

H-Index - 442

eISSN - 1077-3118

pISSN - 0003-6951

DOI - 10.1063/1.3580763

Subject(s) - microbubbles , cavitation , focused ultrasound , ultrasound , transcranial doppler , bubble , biomedical engineering , materials science , sonication , transducer , blood–brain barrier , acoustics , neuroscience , medicine , central nervous system , radiology , computer science , physics , psychology , parallel computing

In vivo transcranial and noninvasive cavitation detection with blood-brain barrier (BBB) opening in nonhuman primates is hereby reported. The BBB in monkeys was opened transcranically using focused ultrasound (FUS) in conjunction with microbubbles. A passive cavitation detector, confocal with the FUS transducer, was used to identify and monitor the bubble behavior. During sonication, the cavitation spectrum, which was found to be region-, pressure-, and bubble-dependent, provided real-time feedback regarding the opening occurrence and its properties. These findings demonstrate feasibility of transcranial, cavitation-guided BBB opening using FUS and microbubbles in noninvasive human applications.

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