Hybrid optimal scheduling for intermittent androgen suppression of prostate cancer | Zendy

Yoshito Hirata | Zendy; Mario di Bernardo | Zendy; Nicholas Bruchovsky | Zendy; Kazuyuki Aihara | Zendy

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Hybrid optimal scheduling for intermittent androgen suppression of prostate cancer

Author(s) -

Yoshito Hirata,

Mario di Bernardo,

Nicholas Bruchovsky,

Kazuyuki Aihara

Publication year - 2010

Publication title -

chaos an interdisciplinary journal of nonlinear science

Language(s) - English

Resource type - Journals

eISSN - 1089-7682

pISSN - 1054-1500

DOI - 10.1063/1.3526968

Subject(s) - prostate cancer , schedule , population , medicine , androgen suppression , piecewise linear function , prostate , prostate specific antigen , computer science , oncology , cancer , urology , mathematics , environmental health , operating system , geometry

We propose a method for achieving an optimal protocol of intermittent androgen suppression for the treatment of prostate cancer. Since the model that reproduces the dynamical behavior of the surrogate tumor marker, prostate specific antigen, is piecewise linear, we can obtain an analytical solution for the model. Based on this, we derive conditions for either stopping or delaying recurrent disease. The solution also provides a design principle for the most favorable schedule of treatment that minimizes the rate of expansion of the malignant cell populatio

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