Organic field-effect transistor-based biosensors functionalized with protein receptors | Zendy

Francesco Maddalena | Zendy; Marjon J. Kuiper | Zendy; Bert Poolman | Zendy; Frank Brouwer | Zendy; Jan C. Hummelen | Zendy; Dago M. de Leeuw | Zendy; Bert de Boer | Zendy; Paul W. M. Blom | Zendy

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Organic field-effect transistor-based biosensors functionalized with protein receptors

Author(s) -

Francesco Maddalena,

Marjon J. Kuiper,

Bert Poolman,

Frank Brouwer,

Jan C. Hummelen,

Dago M. de Leeuw,

Bert de Boer,

Paul W. M. Blom

Publication year - 2010

Publication title -

journal of applied physics

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 0.699

H-Index - 319

eISSN - 1089-7550

pISSN - 0021-8979

DOI - 10.1063/1.3518681

Subject(s) - biosensor , field effect transistor , covalent bond , transistor , materials science , organic field effect transistor , dielectric , chemistry , threshold voltage , ion , sulfate , nanotechnology , optoelectronics , analytical chemistry (journal) , voltage , electrical engineering , chromatography , organic chemistry , engineering

An organic field-effect transistor with integrated proteins (Bio-FET) for sensing of sulfate ions is presented. A sulfate receptor was engineered to contain a thiol group for surface-anchoring without affecting its binding activity. The modified receptor was covalently coupled to a maleimide-functionalized polystyrene layer, and integrated as gate dielectric in a dual-gate transducer. The binding of sulfate ions in dry conditions was detected by a shift in the threshold voltage. Combined with surface density measurements by atomic force microscopy , an effective charge of −1.7q per protein was found, as expected from the Bio-FET operation model

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