The protein folding transition state: Insights from kinetics and thermodynamics | Zendy

Rui D. M. Travasso | Zendy; Patrícia F. N. Faísca | Zendy; Antonio Rey | Zendy

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The protein folding transition state: Insights from kinetics and thermodynamics

Author(s) -

Rui D. M. Travasso,

Patrícia F. N. Faísca,

Antonio Rey

Publication year - 2010

Publication title -

the journal of chemical physics

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 1.071

H-Index - 357

eISSN - 1089-7690

pISSN - 0021-9606

DOI - 10.1063/1.3485286

Subject(s) - kinetics , chemistry , protein folding , thermodynamics , folding (dsp implementation) , kinetic energy , reaction coordinate , transition state theory , downhill folding , transition state , monte carlo method , energy landscape , statistical physics , phi value analysis , reaction rate constant , physics , mathematics , biochemistry , statistics , quantum mechanics , electrical engineering , engineering , catalysis

We perform extensive lattice Monte Carlo simulations of protein folding to construct and compare the equilibrium and the kinetic transition state ensembles of a model protein that folds to the native state with two-state kinetics. The kinetic definition of the transition state is based on the folding probability analysis method, and therefore on the selection of conformations with 0.4

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