Open AccessDifferentiation of Normal and Malignant Breast Tissues using Infrared Spectroscopy
Author(s) -
Ranjana Mehrotra,
Deepak K. Jangir,
Alka Gupta,
H.C. Kandpal,
V. K. Vaidyan,
V. S. Jayakumar
Publication year - 2008
Publication title -
aip conference proceedings
Language(s) - English
Resource type - Conference proceedings
SCImago Journal Rank - 0.177
H-Index - 75
eISSN - 1551-7616
pISSN - 0094-243X
DOI - 10.1063/1.3046194
Subject(s) - infrared spectroscopy , infrared , malignancy , fourier transform infrared spectroscopy , nuclear magnetic resonance , pathology , fourier transform , spectral line , nucleic acid , spectroscopy , chemistry , materials science , medicine , optics , biochemistry , mathematics , physics , mathematical analysis , organic chemistry , quantum mechanics , astronomy
Infrared spectra of carcinomatous and their normal fore bearing tissues were collected in the 600 cm−1 to 4000 cm−1 region. Fourier Transform Infrared (FTIR) data of infiltrating ductal carcinoma of breast with different grades of malignancy from patients of different age groups were analyzed. Infrared spectra demonstrate significant spectral differences between the tumor sections of normal and the malignant breast tissues. In particular, changes in frequency and intensity in the spectra of protein, nucleic acid and glycogen were observed. This allows to make a qualitative and semi quantitative evaluation of the changes in proliferation activities from normal to diseased tissue. The findings establish a framework for additional studies, which may enable us to establish a relation of the diseased state with its infrared spectra.
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