Differential surface stress sensor for detection of chemical and biological species | Zendy

K. H. Kang | Zendy; Marit NilsenHamilton | Zendy; Pranav Shrotriya | Zendy

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Differential surface stress sensor for detection of chemical and biological species

Author(s) -

K. H. Kang,

Marit NilsenHamilton,

Pranav Shrotriya

Publication year - 2008

Publication title -

applied physics letters

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 1.182

H-Index - 442

eISSN - 1077-3118

pISSN - 0003-6951

DOI - 10.1063/1.2996411

Subject(s) - cantilever , analyte , surface stress , materials science , interferometry , biosensor , stress (linguistics) , affinities , chemical sensor , nanotechnology , optoelectronics , analytical chemistry (journal) , chemistry , biological system , optics , physics , chromatography , electrode , composite material , linguistics , philosophy , surface energy , stereochemistry , biology

We report a sensor consisting of two micromachined cantilevers (a sensing/reference pair) that is suitable for detection of chemical and biological species. The sensing strategy involves coating the sensing cantilever with receptors that have high affinities for the analyte. The presence of analyte is detected by determining the differential surface stress associated with its adsorption/absorption to the sensing cantilever. An interferometric technique is utilized to measure the differential bending of the sensing cantilever with respect to reference. Surface stress associated with hybridization of single stranded DNA is measured to demonstrate the unique advantages of the sensor.

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