Noise analysis and sensitivity enhancement in immunomagnetic nanomechanical biosensors | Zendy

Kutay İçöz | Zendy; Brian D. Iverson | Zendy; Cagri A. Savran | Zendy

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Noise analysis and sensitivity enhancement in immunomagnetic nanomechanical biosensors

Author(s) -

Kutay İçöz,

Brian D. Iverson,

Cagri A. Savran

Publication year - 2008

Publication title -

applied physics letters

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 1.182

H-Index - 442

eISSN - 1077-3118

pISSN - 0003-6951

DOI - 10.1063/1.2980036

Subject(s) - cantilever , biosensor , deflection (physics) , materials science , streptavidin , bovine serum albumin , nanotechnology , acoustics , nuclear magnetic resonance , chemistry , chromatography , optics , biotin , physics , composite material , biochemistry

We report noise and detection limitations in cantilever-based immunomagnetic biosensors. A differential cantilever system with sensing and control arms was used whereby the control arm was passivated with bovine serum albumin (BSA) and the sensing arm was functionalized with biotin-BSA. Streptavidin-coated magnetic beads were exposed to cantilever arms. An oscillatory magnetic field induced a magnetic force on the beads which caused a relative deflection of the sensing arm. Increasing the excitation frequency suppressed the 1∕f noise by 100-fold, resulting in a deflection resolution of 0.065A in air.

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