Impedance spectroscopy using maximum length sequences: Application to single cell analysis | Zendy

Shady Gawad | Zendy; Tao Sun | Zendy; Nicolas G. Green | Zendy; Hywel Morgan | Zendy

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Impedance spectroscopy using maximum length sequences: Application to single cell analysis

Author(s) -

Shady Gawad,

Tao Sun,

Nicolas G. Green,

Hywel Morgan

Publication year - 2007

Publication title -

review of scientific instruments

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 0.605

H-Index - 165

eISSN - 1089-7623

pISSN - 0034-6748

DOI - 10.1063/1.2737751

Subject(s) - microsecond , dielectric spectroscopy , electrical impedance , materials science , broadband , bandwidth (computing) , acoustics , computer science , optics , physics , telecommunications , electrode , quantum mechanics , electrochemistry

A maximum length sequence (MLS) is used to perform broadband impedance spectroscopy on a dielectric sample. The method has a number of advantages over other pulse-based or frequency sweep techniques. It requires the application of a very short sequence of voltage steps in the microsecond range and therefore allows the measurement of time-dependent impedance of a sample with high temporal resolution over a large bandwidth. The technique is demonstrated using a time-invariant passive RC network. The impedance of single biological cell flowing in a microfluidic channel is also measured, showing that MLS is an ideal method for high speed impedance analysis.

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