Straightforward biodegradable nanoparticle generation through megahertz-order ultrasonic atomization | Zendy

Gareth M. Forde | Zendy; James Friend | Zendy; Tom Williamson | Zendy

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Straightforward biodegradable nanoparticle generation through megahertz-order ultrasonic atomization

Author(s) -

Gareth M. Forde,

James Friend,

Tom Williamson

Publication year - 2006

Publication title -

applied physics letters

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 1.182

H-Index - 442

eISSN - 1077-3118

pISSN - 0003-6951

DOI - 10.1063/1.2221914

Subject(s) - nanoparticle , dispersity , piston (optics) , polymer , chemical engineering , materials science , acetone , yield (engineering) , sodium dodecyl sulfate , chemistry , nanotechnology , polymer chemistry , composite material , chromatography , organic chemistry , optics , physics , engineering , wavefront

Simple and reliable formation of biodegradable nanoparticles formed from poly-ε-caprolactone was achieved using 1.645 MHz piston atomization of a source fluid of 0.5% w/v of the polymer dissolved in acetone; the particles were allowed to descend under gravity in air 8 cm into a 1 mM solution of sodium dodecyl sulfate. After centrifugation to remove surface agglomerations, a symmetric monodisperse distribution of particles φ 186 nm (SD=5.7, n=6) was obtained with a yield of 65.2%. © 2006 American Institute of Physics

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