Numerical Simulation of Diffusion of Second Messengers cGMP and Ca2+ in Rod Photoreceptor Outer Segment of Vertebrates | Zendy

Harihar Khanal | Zendy

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Numerical Simulation of Diffusion of Second Messengers cGMP and Ca2+ in Rod Photoreceptor Outer Segment of Vertebrates

Author(s) -

Harihar Khanal

Publication year - 2003

Publication title -

aip conference proceedings

Language(s) - English

Resource type - Conference proceedings

SCImago Journal Rank - 0.177

H-Index - 75

eISSN - 1551-7616

pISSN - 0094-243X

DOI - 10.1063/1.1584888

Subject(s) - diffusion , second messenger system , biophysics , cyclic gmp , computer science , biological system , physics , biology , microbiology and biotechnology , nuclear magnetic resonance , intracellular , thermodynamics , enzyme

A crucial step in the process of phototransduction, whereby light is converted into an electrical response in retinal rod and cone photoreceptors, involves interaction and diffusion of cytoplasmic signaling molecules, termed second messengers, in the cytosol. A computational model for the interaction and diffusion of the second messengers (cyclic Guanosine Monophosphate and Calcium) during the activation phase of phototransduction in retinal rod cells is described and results of numerical simulations are presented.

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