DNA microarray inspection by interference microscopy | Zendy

Laurent Vabre | Zendy; A. Dubois | Zendy; M. C. Potier | Zendy; J.L. Stehlé | Zendy; Claude Boccara | Zendy

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DNA microarray inspection by interference microscopy

Author(s) -

Laurent Vabre,

A. Dubois,

M. C. Potier,

J.L. Stehlé,

Claude Boccara

Publication year - 2001

Publication title -

review of scientific instruments

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 0.605

H-Index - 165

eISSN - 1089-7623

pISSN - 0034-6748

DOI - 10.1063/1.1369625

Subject(s) - microscope slide , dna microarray , microscope , spots , homogeneity (statistics) , materials science , microscopy , dna , optics , computer science , biology , genetics , physics , gene , gene expression , botany , machine learning

International audienceDNA microarrays are important new objects for biologists, offering new methods for high speed genetic studies. Many of them are manufactured by depositing small spots, containing DNA molecules, on a coated glass slide. The quality of the spots ~homogeneity, shape! is an important factor in the quality of the analysis. We have built a Linnik-type interference microscope providing three-dimensional ~3D! topographic images of surfaces with a sensitivity of a few tens of picometers in height. This microscope has been applied to obtain 3D images of DNA microarray spots. We demonstrate the ability of the system to reveal the quality of DNA spots

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