HLA Match Likelihoods for Hematopoietic Stem-Cell Grafts in the U.S. Registry
Author(s) -
Loren Gragert,
Mary Eapen,
Eric Williams,
John L. Freeman,
Stephen R. Spellman,
Robert L. Baitty,
Robert J. Hartzman,
J. Douglas Rizzo,
Mary M. Horowitz,
Dennis L. Confer,
Martin Maiers
Publication year - 2014
Publication title -
new england journal of medicine
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 19.889
H-Index - 1030
eISSN - 1533-4406
pISSN - 0028-4793
DOI - 10.1056/nejmsa1311707
Subject(s) - medicine , cord blood , human leukocyte antigen , umbilical cord , hematopoietic stem cell transplantation , population , transplantation , immunology , antigen , environmental health
Hematopoietic stem-cell transplantation (HSCT) is a potentially lifesaving therapy for several blood cancers and other diseases. For patients without a suitable related HLA-matched donor, unrelated-donor registries of adult volunteers and banked umbilical cord-blood units, such as the Be the Match Registry operated by the National Marrow Donor Program (NMDP), provide potential sources of donors. Our goal in the present study was to measure the likelihood of finding a suitable donor in the U.S. registry.
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