Neural-Tube Defects and Antiretroviral Treatment Regimens in Botswana | Zendy

Rebecca Zash | Zendy; Lewis B. Holmes | Zendy; Modiegi Diseko | Zendy; Denise L. Jacobson | Zendy; Sean S. Brummel | Zendy; Gloria Mayondi | Zendy; Arielle Isaacson | Zendy; Sonya Davey | Zendy; Judith Mabuta | Zendy; Mompati Mmalane | Zendy; Tendani Gaolathe | Zendy; Max Essex | Zendy; Shahin Lockman | Zendy; Joseph Makhema | Zendy; Roger Shapiro | Zendy

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Neural-Tube Defects and Antiretroviral Treatment Regimens in Botswana

Author(s) -

Rebecca Zash,

Lewis B. Holmes,

Modiegi Diseko,

Denise L. Jacobson,

Sean S. Brummel,

Gloria Mayondi,

Arielle Isaacson,

Sonya Davey,

Judith Mabuta,

Mompati Mmalane,

Tendani Gaolathe,

Max Essex,

Shahin Lockman,

Joseph Makhema,

Roger Shapiro

Publication year - 2019

Publication title -

new england journal of medicine

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 19.889

H-Index - 1030

eISSN - 1533-4406

pISSN - 0028-4793

DOI - 10.1056/nejmoa1905230

Subject(s) - neural tube , antiretroviral treatment , antiretroviral therapy , tube (container) , human immunodeficiency virus (hiv) , medicine , virology , intensive care medicine , biology , fishery , engineering , viral load , waste management , embryo

A preliminary safety signal for neural-tube defects was previously reported in association with dolutegravir exposure from the time of conception, which has affected choices of antiretroviral treatment (ART) for human immunodeficiency virus (HIV)-infected women of reproductive potential. The signal can now be evaluated with data from follow-up of additional pregnancies.

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