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Clinical and Genomic Risk to Guide the Use of Adjuvant Therapy for Breast Cancer
Author(s) -
Joseph A. Sparano,
Robert J. Gray,
Peter M. Ravdin,
Della Makower,
Kathleen I. Pritchard,
Kathy S. Albain,
Daniel F. Hayes,
Charles E. Geyer,
Elizabeth Claire Dees,
Matthew P. Goetz,
John A. Olson,
Tracy Lively,
Sunil Badve,
Thomas J. Saphner,
Lynne I. Wagner,
Timothy J. Whelan,
Matthew J. Ellis,
Soonmyung Paik,
William C. Wood,
Maccon Keane,
Henry Gómez,
Pavan S. Reddy,
Timothy F. Goggins,
Ingrid A. Mayer,
Adam Brufsky,
Deborah Toppmeyer,
Virginia Kaklamani,
Jeffrey L. Berenberg,
Jeffrey S. Abrams,
George W. Sledge
Publication year - 2019
Publication title -
new england journal of medicine
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 19.889
H-Index - 1030
eISSN - 1533-4406
pISSN - 0028-4793
DOI - 10.1056/nejmoa1904819
Subject(s) - breast cancer , medicine , oncology , adjuvant , adjuvant therapy , adjuvant chemotherapy , chemotherapy , cancer
The use of adjuvant chemotherapy in patients with breast cancer may be guided by clinicopathological factors and a score based on a 21-gene assay to determine the risk of recurrence. Whether the level of clinical risk of breast cancer recurrence adds prognostic information to the recurrence score is not known.

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