Tagraxofusp in Blastic Plasmacytoid Dendritic-Cell Neoplasm | Zendy

Naveen Pemmaraju | Zendy; Andrew A. Lane | Zendy; Kendra Sweet | Zendy; Anthony S. Stein | Zendy; Sumithira Vasu | Zendy; William Blum | Zendy; David A. Rizzieri | Zendy; Eunice S. Wang | Zendy; Madeleine Duvic | Zendy; J. Mark Sloan | Zendy; Sharon Spence | Zendy; Shay Shemesh | Zendy; Christopher Brooks | Zendy; John Balser | Zendy; Ivan Bergstein | Zendy; Jeffrey E. Lancet | Zendy; Hagop M. Kantarjian | Zendy; Marina Konopleva | Zendy

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Tagraxofusp in Blastic Plasmacytoid Dendritic-Cell Neoplasm

Author(s) -

Naveen Pemmaraju,

Andrew A. Lane,

Kendra Sweet,

Anthony S. Stein,

Sumithira Vasu,

William Blum,

David A. Rizzieri,

Eunice S. Wang,

Madeleine Duvic,

J. Mark Sloan,

Sharon Spence,

Shay Shemesh,

Christopher Brooks,

John Balser,

Ivan Bergstein,

Jeffrey E. Lancet,

Hagop M. Kantarjian,

Marina Konopleva

Publication year - 2019

Publication title -

new england journal of medicine

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 19.889

H-Index - 1030

eISSN - 1533-4406

pISSN - 0028-4793

DOI - 10.1056/nejmoa1815105

Subject(s) - interleukin 3 receptor , plasmacytoid dendritic cell , diphtheria toxin , medicine , dendritic cell , cancer research , immunology , virology , leukemia , biology , toxin , antigen , microbiology and biotechnology

Blastic plasmacytoid dendritic-cell neoplasm (BPDCN) is an aggressive hematologic cancer that is caused by transformed plasmacytoid dendritic cells that overexpress interleukin-3 receptor subunit alpha (IL3RA or CD123). Tagraxofusp (SL-401) is a CD123-directed cytotoxin consisting of human interleukin-3 fused to truncated diphtheria toxin.

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