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Levothyroxine in Women with Thyroid Peroxidase Antibodies before Conception
Author(s) -
Rima DhillonSmith,
Lee Middleton,
Kirandeep K Sunner,
Versha Cheed,
Krys Baker,
Samantha Farrell-Carver,
Ruth Bender-Atik,
Rina Agrawal,
Kalsang Bhatia,
Edmond EdiOsagie,
Tarek Ghobara,
Pratima Gupta,
D. Jurkovic,
Yacoub Khalaf,
Marjory MacLean,
Christopher J. McCabe,
Khashia Mulbagal,
Natalie Nunes,
Caroline Overton,
Siobhan Quenby,
Raj Rai,
Nick RaineFenning,
Lauren Robinson,
Jackie Ross,
Andrew Sizer,
Rachel Small,
Alex Tan,
Martyn Underwood,
Mark D. Kilby,
Kristien Boelaert,
Jane Daniels,
Shakila Thangaratinam,
ShiaoYng Chan,
Arri Coomarasamy
Publication year - 2019
Publication title -
new england journal of medicine
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 19.889
H-Index - 1030
eISSN - 1533-4406
pISSN - 0028-4793
DOI - 10.1056/nejmoa1812537
Subject(s) - levothyroxine , thyroid peroxidase , peroxidase , medicine , antibody , thyroid , endocrinology , immunology , chemistry , enzyme , biochemistry
Thyroid peroxidase antibodies are associated with an increased risk of miscarriage and preterm birth, even when thyroid function is normal. Small trials indicate that the use of levothyroxine could reduce the incidence of such adverse outcomes.

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