Tafamidis Treatment for Patients with Transthyretin Amyloid Cardiomyopathy | Zendy

Matthew J. Maurer | Zendy; Jeffrey H. Schwartz | Zendy; Balarama Gundapaneni | Zendy; Perry Elliott | Zendy; Giampaolo Merlini | Zendy; Márcia WaddingtonCruz | Zendy; Arnt V. Kristen | Zendy; Martha Grogan | Zendy; Ronald Witteles | Zendy; Thibaud Damy | Zendy; Brian Drachman | Zendy; Sanjiv J. Shah | Zendy; Mazen Hanna | Zendy; Daniel P. Judge | Zendy; Alexandra I. Barsdorf | Zendy; Peter M. Huber | Zendy; Terrell A. Patterson | Zendy; Steve Riley | Zendy; Jennifer Schumacher | Zendy; Michelle Stewart | Zendy; Marla B. Sultan | Zendy; Claudio Rapezzi | Zendy

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Tafamidis Treatment for Patients with Transthyretin Amyloid Cardiomyopathy

Author(s) -

Matthew J. Maurer,

Jeffrey H. Schwartz,

Balarama Gundapaneni,

Perry Elliott,

Giampaolo Merlini,

Márcia WaddingtonCruz,

Arnt V. Kristen,

Martha Grogan,

Ronald Witteles,

Thibaud Damy,

Brian Drachman,

Sanjiv J. Shah,

Mazen Hanna,

Daniel P. Judge,

Alexandra I. Barsdorf,

Peter M. Huber,

Terrell A. Patterson,

Steve Riley,

Jennifer Schumacher,

Michelle Stewart,

Marla B. Sultan,

Claudio Rapezzi

Publication year - 2018

Publication title -

new england journal of medicine

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 19.889

H-Index - 1030

eISSN - 1533-4406

pISSN - 0028-4793

DOI - 10.1056/nejmoa1805689

Subject(s) - transthyretin , hazard ratio , medicine , placebo , clinical endpoint , confidence interval , cardiomyopathy , gastroenterology , cardiology , clinical trial , heart failure , pathology , alternative medicine

Transthyretin amyloid cardiomyopathy is caused by the deposition of transthyretin amyloid fibrils in the myocardium. The deposition occurs when wild-type or variant transthyretin becomes unstable and misfolds. Tafamidis binds to transthyretin, preventing tetramer dissociation and amyloidogenesis.

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