MRI-Guided Thrombolysis for Stroke with Unknown Time of Onset | Zendy

Götz Thomalla | Zendy; Claus Z. Simonsen | Zendy; Florent Boutitie | Zendy; Grethe Andersen | Zendy; Yves Berthezène | Zendy; Bastian Cheng | Zendy; Bharath Kumar Cheripelli | Zendy; TaeHee Cho | Zendy; Franz Fazekas | Zendy; Jens Fiehler | Zendy; Ian Ford | Zendy; Ivana Galinović | Zendy; Susanne Gellißen | Zendy; Amir Golsari | Zendy; Johannes Gregori | Zendy; Matthias Günther | Zendy; Jorge Guibernau | Zendy; Karl Georg Häusler | Zendy; Michael G. Hennerici | Zendy; André Kemmling | Zendy; Jacob Marstrand | Zendy; Boris Modrau | Zendy; Lars Neeb | Zendy; Natàlia Pérez de la Ossa | Zendy; Josep Puig | Zendy; Peter Ringleb | Zendy; Pascal Roy | Zendy; Enno Scheel | Zendy; Wouter J. Schonewille | Zendy; Joaquı́n Serena | Zendy; Stefan Sunaert | Zendy; Kersten Villringer | Zendy; Anke Wouters | Zendy; Vincent Thijs | Zendy; Martin Ebinger | Zendy; Matthias Endres | Zendy; Jochen B. Fiebach | Zendy; Robin Lemmens | Zendy; Keith W. Muir | Zendy; Norbert Nighoghossian | Zendy; Salvador Pedraza | Zendy; Christian Gerloff | Zendy

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MRI-Guided Thrombolysis for Stroke with Unknown Time of Onset

Author(s) -

Götz Thomalla,

Claus Z. Simonsen,

Florent Boutitie,

Grethe Andersen,

Yves Berthezène,

Bastian Cheng,

Bharath Kumar Cheripelli,

TaeHee Cho,

Franz Fazekas,

Jens Fiehler,

Ian Ford,

Ivana Galinović,

Susanne Gellißen,

Amir Golsari,

Johannes Gregori,

Matthias Günther,

Jorge Guibernau,

Karl Georg Häusler,

Michael G. Hennerici,

André Kemmling,

Jacob Marstrand,

Boris Modrau,

Lars Neeb,

Natàlia Pérez de la Ossa,

Josep Puig,

Peter Ringleb,

Pascal Roy,

Enno Scheel,

Wouter J. Schonewille,

Joaquı́n Serena,

Stefan Sunaert,

Kersten Villringer,

Anke Wouters,

Vincent Thijs,

Martin Ebinger,

Matthias Endres,

Jochen B. Fiebach,

Robin Lemmens,

Keith W. Muir,

Norbert Nighoghossian,

Salvador Pedraza,

Christian Gerloff

Publication year - 2018

Publication title -

new england journal of medicine

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 19.889

H-Index - 1030

eISSN - 1533-4406

pISSN - 0028-4793

DOI - 10.1056/nejmoa1804355

Subject(s) - thrombolysis , medicine , magnetic resonance imaging , stroke (engine) , cardiology , cerebral infarction , infarction , acute stroke , radiology , tissue plasminogen activator , myocardial infarction , ischemia , engineering , mechanical engineering

Under current guidelines, intravenous thrombolysis is used to treat acute stroke only if it can be ascertained that the time since the onset of symptoms was less than 4.5 hours. We sought to determine whether patients with stroke with an unknown time of onset and features suggesting recent cerebral infarction on magnetic resonance imaging (MRI) would benefit from thrombolysis with the use of intravenous alteplase.

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