Dupilumab Efficacy and Safety in Moderate-to-Severe Uncontrolled Asthma
Author(s) -
Mario Castro,
Jonathan Corren,
Ian Pavord,
Jorge Máspero,
Sally E. Wenzel,
Klaus F. Rabe,
William W. Busse,
Linda Ford,
Lawrence Sher,
J. Mark FitzGerald,
Constance H. Katelaris,
Yuji Tohda,
Bingzhi Zhang,
Heribert Staudinger,
Gianluca Pirozzi,
Nikhil Amin,
Marcella Ruddy,
Bolanle Akinlade,
Asif Khan,
Jingdong Chao,
Renata Martincova,
Neil M.H. Graham,
Jennifer D. Hamilton,
Brian N. Swanson,
Neil Stahl,
George D. Yancopoulos,
Ariel Teper
Publication year - 2018
Publication title -
new england journal of medicine
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 19.889
H-Index - 1030
eISSN - 1533-4406
pISSN - 0028-4793
DOI - 10.1056/nejmoa1804092
Subject(s) - dupilumab , medicine , asthma , monoclonal antibody , monoclonal , clinical efficacy , interleukin , immunology , antibody , cytokine
Dupilumab is a fully human anti-interleukin-4 receptor α monoclonal antibody that blocks both interleukin-4 and interleukin-13 signaling. We assessed its efficacy and safety in patients with uncontrolled asthma.
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