Phase 2 Trial of Ibudilast in Progressive Multiple Sclerosis | Zendy

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Phase 2 Trial of Ibudilast in Progressive Multiple Sclerosis

Author(s) -

Robert J. Fox,

Christopher S. Coffey,

Robin Conwit,

Merit Cudkowicz,

Trevis Gleason,

Andrew Goodman,

Eric C. Klawiter,

Kazuko Matsuda,

Michelle McGovern,

Robert T. Naismith,

Akshata Ashokkumar,

Janel Barnes,

Dixie Ecklund,

Elizabeth Klingner,

Maxine Koepp,

Jeffrey D. Long,

Sneha Natarajan,

Brenda Thornell,

Jon Yankey,

Robert Bermel,

Josef P. Debbins,

Xuemei Huang,

Patricia Jagodnik,

Mark J. Lowe,

Kunio Nakamura,

Sridar Narayanan,

Ken Sakaie,

Bhaskar Thoomukuntla,

Xiaopeng Zhou,

Stephen Krieger,

Enríque Alvarez,

Michelle Apperson,

Khurram Bashir,

Bruce A. Cohen,

Patricia K. Coyle,

Silvia Delgado,

L. Dana DeWitt,

Angela Flores,

Barbara S. Giesser,

Myla Goldman,

Burk Jubelt,

Neil Lava,

Sharon Lynch,

Harold L. Moses,

Daniel Ontaneda,

Jai Perumal,

Michael K. Racke,

Pavle Repovic,

Claire Riley,

Christopher Severson,

Shlomo Shinnar,

Valerie Suski,

Bianca Weinstock-Guttman,

Vijayshree Yadav,

Aram Zabeti

Publication year - 2018

Publication title -

new england journal of medicine

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 19.889

H-Index - 1030

eISSN - 1533-4406

pISSN - 0028-4793

DOI - 10.1056/nejmoa1803583

Subject(s) - phase (matter) , medicine , multiple sclerosis , psychiatry , physics , quantum mechanics

There are limited treatments for progressive multiple sclerosis. Ibudilast inhibits several cyclic nucleotide phosphodiesterases, macrophage migration inhibitory factor, and toll-like receptor 4 and can cross the blood-brain barrier, with potential salutary effects in progressive multiple sclerosis.

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