Genetics and Pathogenesis of Diffuse Large B-Cell Lymphoma | Zendy

Roland Schmitz | Zendy; George W. Wright | Zendy; Da Wei Huang | Zendy; Calvin A. Johnson | Zendy; James D. Phelan | Zendy; James Q. Wang | Zendy; Sandrine Roulland | Zendy; Monica Kasbekar | Zendy; Ryan M. Young | Zendy; Arthur L. Shaffer | Zendy; Daniel J. Hodson | Zendy; Wenming Xiao | Zendy; Xin Yu | Zendy; Yandan Yang | Zendy; Hong Zhao | Zendy; Weihong Xu | Zendy; Xuelu Liu | Zendy; Bin Zhou | Zendy; Wei Du | Zendy; Wing C. Chan | Zendy; Elaine S. Jaffe | Zendy; Randy D. Gascoyne | Zendy; Joseph M. Connors | Zendy; Elı́as Campo | Zendy; Armando LópezGuillermo | Zendy; Andreas Rosenwald | Zendy; German Ott | Zendy; Jan Delabie | Zendy; Lisa M. Rimsza | Zendy; Kevin Tay Kuang Wei | Zendy; Andrew D. Zelenetz | Zendy; John P. Leonard | Zendy; Nancy L. Bartlett | Zendy; Bao Tran | Zendy; Jyoti Shetty | Zendy; Yongmei Zhao | Zendy; Dan Soppet | Zendy; Stefania Pittaluga | Zendy; Wyndham H. Wilson | Zendy; Louis M. Staudt | Zendy

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Genetics and Pathogenesis of Diffuse Large B-Cell Lymphoma

Author(s) -

Roland Schmitz,

George W. Wright,

Da Wei Huang,

Calvin A. Johnson,

James D. Phelan,

James Q. Wang,

Sandrine Roulland,

Monica Kasbekar,

Ryan M. Young,

Arthur L. Shaffer,

Daniel J. Hodson,

Wenming Xiao,

Xin Yu,

Yandan Yang,

Hong Zhao,

Weihong Xu,

Xuelu Liu,

Bin Zhou,

Wei Du,

Wing C. Chan,

Elaine S. Jaffe,

Randy D. Gascoyne,

Joseph M. Connors,

Elı́as Campo,

Armando LópezGuillermo,

Andreas Rosenwald,

German Ott,

Jan Delabie,

Lisa M. Rimsza,

Kevin Tay Kuang Wei,

Andrew D. Zelenetz,

John P. Leonard,

Nancy L. Bartlett,

Bao Tran,

Jyoti Shetty,

Yongmei Zhao,

Dan Soppet,

Stefania Pittaluga,

Wyndham H. Wilson,

Louis M. Staudt

Publication year - 2018

Publication title -

new england journal of medicine

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 19.889

H-Index - 1030

eISSN - 1533-4406

pISSN - 0028-4793

DOI - 10.1056/nejmoa1801445

Subject(s) - biology , germinal center , diffuse large b cell lymphoma , lymphoma , cell of origin , gene expression profiling , genetics , gene , pathogenesis , b cell , cancer research , gene expression , immunology , antibody

Diffuse large B-cell lymphomas (DLBCLs) are phenotypically and genetically heterogeneous. Gene-expression profiling has identified subgroups of DLBCL (activated B-cell-like [ABC], germinal-center B-cell-like [GCB], and unclassified) according to cell of origin that are associated with a differential response to chemotherapy and targeted agents. We sought to extend these findings by identifying genetic subtypes of DLBCL based on shared genomic abnormalities and to uncover therapeutic vulnerabilities based on tumor genetics.

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