Oral Plasma Kallikrein Inhibitor for Prophylaxis in Hereditary Angioedema | Zendy

Emel AygörenPürsün | Zendy; Anette Bygum | Zendy; Vesna GrivchevaPanovska | Zendy; Markus Magerl | Zendy; Jochen Graff | Zendy; Urs C. Steiner | Zendy; O. Fain | Zendy; Aarnoud Huissoon | Zendy; Tamar Kinaciyan | Zendy; Henriette Farkas | Zendy; Ramón Lleonart | Zendy; Hilary Longhurst | Zendy; William Rae | Zendy; Massimo Triggiani | Zendy; Werner Aberer | Zendy; Mauro Cancian | Zendy; Andrea Zanichelli | Zendy; William Smith | Zendy; M. L. Baeza | Zendy; A. DuThanh | Zendy; Mark Gompels | Zendy; Teresa González-Quevedo | Zendy; Jens Greve | Zendy; Mar Guilarte | Zendy; Constance H. Katelaris | Zendy; Sylvia Dobo | Zendy; Melanie Cornpropst | Zendy; Desiree Clemons | Zendy; Fang Lei | Zendy; Phil Collis | Zendy; William Sheridan | Zendy; Marcus Maurer | Zendy; Marco Cicardi | Zendy

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Oral Plasma Kallikrein Inhibitor for Prophylaxis in Hereditary Angioedema

Author(s) -

Emel AygörenPürsün,

Anette Bygum,

Vesna GrivchevaPanovska,

Markus Magerl,

Jochen Graff,

Urs C. Steiner,

O. Fain,

Aarnoud Huissoon,

Tamar Kinaciyan,

Henriette Farkas,

Ramón Lleonart,

Hilary Longhurst,

William Rae,

Massimo Triggiani,

Werner Aberer,

Mauro Cancian,

Andrea Zanichelli,

William Smith,

M. L. Baeza,

A. DuThanh,

Mark Gompels,

Teresa González-Quevedo,

Jens Greve,

Mar Guilarte,

Constance H. Katelaris,

Sylvia Dobo,

Melanie Cornpropst,

Desiree Clemons,

Fang Lei,

Phil Collis,

William Sheridan,

Marcus Maurer,

Marco Cicardi

Publication year - 2018

Publication title -

new england journal of medicine

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 19.889

H-Index - 1030

eISSN - 1533-4406

pISSN - 0028-4793

DOI - 10.1056/nejmoa1716995

Subject(s) - hereditary angioedema , kallikrein , angioedema , medicine , bradykinin , c1 inhibitor , pharmacodynamics , pharmacology , pharmacokinetics , icatibant , dermatology , enzyme , biochemistry , biology , receptor

Hereditary angioedema is a life-threatening illness caused by mutations in the gene encoding C1 inhibitor (also called C1 esterase inhibitor) that lead to overactivation of the kallikrein-bradykinin cascade. BCX7353 is a potent oral small-molecule inhibitor of plasma kallikrein with a pharmacokinetic and pharmacodynamic profile that may help prevent angioedema attacks.

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