Safety and Side Effects of Rifampin versus Isoniazid in Children
Author(s) -
Thierno Diallo,
Mèli Adjobimey,
Rovina Ruslami,
Anete Trajman,
Oumou Bah Sow,
Joseph Obeng Baah,
Guy B. Marks,
Richard Long,
Kevin Elwood,
David Zielinski,
M. Gninafon,
Diah Asri Wulandari,
Lika Apriani,
Chantal Valiquette,
Federica Fregonese,
Karen Hornby,
Peizhi Li,
Philip C. Hill,
Kevin Schwartzman,
Andrea Benedetti,
Dick Menzies
Publication year - 2018
Publication title -
new england journal of medicine
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 19.889
H-Index - 1030
eISSN - 1533-4406
pISSN - 0028-4793
DOI - 10.1056/nejmoa1714284
Subject(s) - isoniazid , side effect (computer science) , medicine , tuberculosis , computer science , programming language , pathology
The treatment of latent infection with Mycobacterium tuberculosis is important in children because of their vulnerability to life-threatening forms of tuberculosis disease. The current standard treatment - 9 months of isoniazid - has been associated with poor adherence and toxic effects, which have hampered the effectiveness of the drug. In adults, treatment with 4 months of rifampin has been shown to be safer and to have higher completion rates than 9 months of isoniazid.
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