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Duration of Adjuvant Chemotherapy for Stage III Colon Cancer
Author(s) -
Axel Grothey,
Alberto Sobrero,
Anthony F. Shields,
Takayuki Yoshino,
James Paul,
Julien Taı̈eb,
John Souglakos,
Qian Shi,
Rachel Kerr,
Roberto Labianca,
Jeffrey A. Meyerhardt,
Déwi Vernerey,
Takeharu Yamanaka,
Ioannis Boukovinas,
Jeffrey P. Meyers,
Lindsay A. Renfro,
Doniedzwiecki,
Toshiaki Watanabe,
Valter Torri,
Mark Saunders,
Daniel J. Sargent,
Thierry André,
Timothy Iveson
Publication year - 2018
Publication title -
new england journal of medicine
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 19.889
H-Index - 1030
eISSN - 1533-4406
pISSN - 0028-4793
DOI - 10.1056/nejmoa1713709
Subject(s) - oxaliplatin , medicine , regimen , colorectal cancer , stage (stratigraphy) , adjuvant , oncology , duration (music) , adjuvant chemotherapy , adjuvant therapy , chemotherapy , cancer , art , paleontology , literature , breast cancer , biology
Since 2004, a regimen of 6 months of treatment with oxaliplatin plus a fluoropyrimidine has been standard adjuvant therapy in patients with stage III colon cancer. However, since oxaliplatin is associated with cumulative neurotoxicity, a shorter duration of therapy could spare toxic effects and health expenditures.

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