Antifungal Combinations for Treatment of Cryptococcal Meningitis in Africa | Zendy

Síle F. Molloy | Zendy; Cecilia Kanyama | Zendy; Robert S. Heyderman | Zendy; Angela Loyse | Zendy; Charles Kouanfack | Zendy; Duncan Chanda | Zendy; Sayoki Mfinanga | Zendy; Elvis Temfack | Zendy; Shabir Lakhi | Zendy; Sokoine Lesikari | Zendy; Adrienne K Chan | Zendy; Neil Stone | Zendy; Newton Kalata | Zendy; Natasha Karunaharan | Zendy; Katherine M. Gaskell | Zendy; Mary Peirse | Zendy; Jayne Ellis | Zendy; Chimwemwe Chawinga | Zendy; Sandrine Sa’a Lontsi | Zendy; Jean-Gilbert Ndong | Zendy; Philip Bright | Zendy; Duncan Lupiya | Zendy; Tao Chen | Zendy; John Bradley | Zendy; Jack Adams | Zendy; Charles van der Horst | Zendy; Joep J. van Oosterhout | Zendy; Victor Sini | Zendy; Yacouba Njankouo Mapoure | Zendy; Peter Mwaba | Zendy; Tihana Bicanic | Zendy; David G. Lalloo | Zendy; Duolao Wang | Zendy; Mina C. Hosseinipour | Zendy; Olivier Lortholary | Zendy; Shabbar Jaffar | Zendy; Thomas S. Harrison | Zendy

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Antifungal Combinations for Treatment of Cryptococcal Meningitis in Africa

Author(s) -

Síle F. Molloy,

Cecilia Kanyama,

Robert S. Heyderman,

Angela Loyse,

Charles Kouanfack,

Duncan Chanda,

Sayoki Mfinanga,

Elvis Temfack,

Shabir Lakhi,

Sokoine Lesikari,

Adrienne K Chan,

Neil Stone,

Newton Kalata,

Natasha Karunaharan,

Katherine M. Gaskell,

Mary Peirse,

Jayne Ellis,

Chimwemwe Chawinga,

Sandrine Sa’a Lontsi,

Jean-Gilbert Ndong,

Philip Bright,

Duncan Lupiya,

Tao Chen,

John Bradley,

Jack Adams,

Charles van der Horst,

Joep J. van Oosterhout,

Victor Sini,

Yacouba Njankouo Mapoure,

Peter Mwaba,

Tihana Bicanic,

David G. Lalloo,

Duolao Wang,

Mina C. Hosseinipour,

Olivier Lortholary,

Shabbar Jaffar,

Thomas S. Harrison

Publication year - 2018

Publication title -

new england journal of medicine

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 19.889

H-Index - 1030

eISSN - 1533-4406

pISSN - 0028-4793

DOI - 10.1056/nejmoa1710922

Subject(s) - cryptococcal meningitis , antifungal , cryptococcosis , cryptococcus neoformans , meningitis , medicine , microbiology and biotechnology , biology , virology , immunology , human immunodeficiency virus (hiv) , pediatrics , viral disease

Cryptococcal meningitis accounts for more than 100,000 human immunodeficiency virus (HIV)-related deaths per year. We tested two treatment strategies that could be more sustainable in Africa than the standard of 2 weeks of amphotericin B plus flucytosine and more effective than the widely used fluconazole monotherapy.

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