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Somatic Activating KRAS Mutations in Arteriovenous Malformations of the Brain
Author(s) -
Sergey I. Nikolaev,
Sandra Vetiska,
Ximena Bonilla,
Émilie Boudreau,
Suvi Jauhiainen,
Behnam Rezai Jahromi,
Nadiya Khyzha,
Peter V. DiStefano,
Santeri Suutarinen,
TimRasmus Kiehl,
Vítor Mendes Pereira,
Alexander M. Herman,
Timo Krings,
Hugo Andrade-Barazarte,
Takyee Tung,
Taufik A. Valiante,
Gelareh Zadeh,
Michael Tymianski,
Tuomas Rauramaa,
Seppo YläHerttuala,
Joshua D. Wythe,
Stylianos E. Antonarakis,
Juhana Frösén,
Jason E. Fish,
Ivan Radovanovic
Publication year - 2018
Publication title -
new england journal of medicine
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 19.889
H-Index - 1030
eISSN - 1533-4406
pISSN - 0028-4793
DOI - 10.1056/nejmoa1709449
Subject(s) - arteriovenous malformation , somatic cell , stroke (engine) , intracranial arteriovenous malformations , kras , medicine , germline mutation , pathology , mutation , biology , cerebral angiography , radiology , cancer , genetics , angiography , gene , mechanical engineering , colorectal cancer , engineering
Sporadic arteriovenous malformations of the brain, which are morphologically abnormal connections between arteries and veins in the brain vasculature, are a leading cause of hemorrhagic stroke in young adults and children. The genetic cause of this rare focal disorder is unknown.

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