Clonal Hematopoiesis and Risk of Atherosclerotic Cardiovascular Disease | Zendy

Siddhartha Jaiswal | Zendy; Pradeep Natarajan | Zendy; Alexander J. Silver | Zendy; Christopher J. Gibson | Zendy; Alexander G. Bick | Zendy; Eugenia Shvartz | Zendy; Marie McConkey | Zendy; Namrata Gupta | Zendy; Stacey Gabriel | Zendy; Diego Ardissino | Zendy; Usman Baber | Zendy; Roxana Mehran | Zendy; Valentı́n Fuster | Zendy; John Danesh | Zendy; Philippe Frossard | Zendy; Danish Saleheen | Zendy; Olle Melander | Zendy; Galina K. Sukhova | Zendy; Doneuberg | Zendy; Peter Libby | Zendy; Sekar Kathiresan | Zendy; Benjamin L. Ebert | Zendy

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Clonal Hematopoiesis and Risk of Atherosclerotic Cardiovascular Disease

Author(s) -

Siddhartha Jaiswal,

Pradeep Natarajan,

Alexander J. Silver,

Christopher J. Gibson,

Alexander G. Bick,

Eugenia Shvartz,

Marie McConkey,

Namrata Gupta,

Stacey Gabriel,

Diego Ardissino,

Usman Baber,

Roxana Mehran,

Valentı́n Fuster,

John Danesh,

Philippe Frossard,

Danish Saleheen,

Olle Melander,

Galina K. Sukhova,

Doneuberg,

Peter Libby,

Sekar Kathiresan,

Benjamin L. Ebert

Publication year - 2017

Publication title -

new england journal of medicine

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 19.889

H-Index - 1030

eISSN - 1533-4406

pISSN - 0028-4793

DOI - 10.1056/nejmoa1701719

Subject(s) - medicine , myocardial infarction , coronary artery disease , bone marrow , cardiology , disease , oncology

Clonal hematopoiesis of indeterminate potential (CHIP), which is defined as the presence of an expanded somatic blood-cell clone in persons without other hematologic abnormalities, is common among older persons and is associated with an increased risk of hematologic cancer. We previously found preliminary evidence for an association between CHIP and atherosclerotic cardiovascular disease, but the nature of this association was unclear.

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