Airway Mucin Concentration as a Marker of Chronic Bronchitis | Zendy

Mehmet Kesımer | Zendy; Amina A. Ford | Zendy; Agathe Ceppe | Zendy; Giorgia Radicioni | Zendy; Rui Cao | Zendy; C. William Davis | Zendy; Claire M. Doerschuk | Zendy; Neil E. Alexis | Zendy; Wayne H. Anderson | Zendy; Ashley G. Henderson | Zendy; R. Graham Barr | Zendy; Eugene R. Bleecker | Zendy; Stephanie A. Christenson | Zendy; Christopher B. Cooper | Zendy; MeiLan K. Han | Zendy; Nadia N. Hansel | Zendy; Annette T. Hastie | Zendy; Eric A. Hoffman | Zendy; Richard E. Kanner | Zendy; Fernando J. Martínez | Zendy; Robert Paine | Zendy; Prescott G. Woodruff | Zendy; Wanda K. O’Neal | Zendy; Richard C. Boucher | Zendy

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Airway Mucin Concentration as a Marker of Chronic Bronchitis

Author(s) -

Mehmet Kesımer,

Amina A. Ford,

Agathe Ceppe,

Giorgia Radicioni,

Rui Cao,

C. William Davis,

Claire M. Doerschuk,

Neil E. Alexis,

Wayne H. Anderson,

Ashley G. Henderson,

R. Graham Barr,

Eugene R. Bleecker,

Stephanie A. Christenson,

Christopher B. Cooper,

MeiLan K. Han,

Nadia N. Hansel,

Annette T. Hastie,

Eric A. Hoffman,

Richard E. Kanner,

Fernando J. Martínez,

Robert Paine,

Prescott G. Woodruff,

Wanda K. O’Neal,

Richard C. Boucher

Publication year - 2017

Publication title -

new england journal of medicine

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 19.889

H-Index - 1030

eISSN - 1533-4406

pISSN - 0028-4793

DOI - 10.1056/nejmoa1701632

Subject(s) - medicine , chronic bronchitis , mucin , copd , sputum , mucus , bronchitis , airway , pulmonary disease , obstructive lung disease , asthma , immunology , pathology , surgery , tuberculosis , biology , ecology

Chronic obstructive pulmonary disease (COPD) is characterized by chronic bronchitic and emphysematous components. In one biophysical model, the concentration of mucin on the airway surfaces is hypothesized to be a key variable that controls mucus transport in healthy persons versus cessation of transport in persons with muco-obstructive lung diseases. Under this model, it is postulated that a high mucin concentration produces the sputum and disease progression that are characteristic of chronic bronchitis.

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