Early, Goal-Directed Therapy for Septic Shock — A Patient-Level Meta-Analysis | Zendy

Prism Investigators | Zendy; Kathy Rowan | Zendy; Derek C. Angus | Zendy; Michael Bailey | Zendy; Amber E. Barnato | Zendy; Rinaldo Bellomo | Zendy; Ruth R Canter | Zendy; Timothy J Coats | Zendy; Anthony Delaney | Zendy; Elizabeth Gimbel | Zendy; Richard Grieve | Zendy; David A Harrison | Zendy; Alisa Higgins | Zendy; Belinda Howe | Zendy; David T. Huang | Zendy; John A. Kellum | Zendy; Paul R Mouncey | Zendy; Edvin Music | Zendy; Sandra Peake | Zendy; Francis Pike | Zendy; Michael C. Reade | Zendy; Zia Sadique | Zendy; Mervyn Singer | Zendy; Donald M. Yealy | Zendy

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Early, Goal-Directed Therapy for Septic Shock — A Patient-Level Meta-Analysis

Author(s) -

Prism Investigators,

Kathy Rowan,

Derek C. Angus,

Michael Bailey,

Amber E. Barnato,

Rinaldo Bellomo,

Ruth R Canter,

Timothy J Coats,

Anthony Delaney,

Elizabeth Gimbel,

Richard Grieve,

David A Harrison,

Alisa Higgins,

Belinda Howe,

David T. Huang,

John A. Kellum,

Paul R Mouncey,

Edvin Music,

Sandra Peake,

Francis Pike,

Michael C. Reade,

Zia Sadique,

Mervyn Singer,

Donald M. Yealy

Publication year - 2017

Publication title -

new england journal of medicine

Language(s) - English

Resource type - Journals

eISSN - 1533-4406

pISSN - 0028-4793

DOI - 10.1056/nejmoa1701380

Subject(s) - early goal directed therapy , septic shock , observational study , meta analysis , medicine , intensive care medicine , shock (circulatory) , clinical trial , sepsis , severe sepsis

After a single-center trial and observational studies suggesting that early, goal-directed therapy (EGDT) reduced mortality from septic shock, three multicenter trials (ProCESS, ARISE, and ProMISe) showed no benefit. This meta-analysis of individual patient data from the three recent trials was designed prospectively to improve statistical power and explore heterogeneity of treatment effect of EGDT.

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