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Cancer-Associated Mutations in Endometriosis without Cancer
Author(s) -
Michael S. Anglesio,
Nickolas Papadopoulos,
A. Ayhan,
Tayyebeh M. Nazeran,
Michaël Noë,
Hugo M. Horlings,
Amy Lum,
Siân Jones,
Janine Senz,
Tamer Seckin,
Julie Ho,
RenChin Wu,
Vivian Lac,
Hiroshi Ogawa,
Basile TessierCloutier,
Rami Alhassan,
Amy Wang,
Yuxuan Wang,
Joshua D. Cohen,
Fontayne Wong,
Adnan Hasanovic,
Natasha L. Orr,
Ming Zhang,
Maria Popoli,
Wyatt McMahon,
Laura D. Wood,
Austin K. Mattox,
Catherine Allaire,
James H. Segars,
Christina Williams,
Cristian Tomasetti,
Niki Boyd,
Kenneth W. Kinzler,
C. Blake Gilks,
Luis A. Díaz,
TianLi Wang,
Bert Vogelstein,
Paul J. Yong,
David G. Huntsman,
IeMing Shih
Publication year - 2017
Publication title -
new england journal of medicine
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 19.889
H-Index - 1030
eISSN - 1533-4406
pISSN - 0028-4793
DOI - 10.1056/nejmoa1614814
Subject(s) - endometriosis , medicine , infertility , stroma , cancer , endometrial cancer , pelvic pain , apoptosis , pathology , ovarian cancer , oncology , gynecology , cancer research , immunohistochemistry , surgery , pregnancy , biology , genetics , biochemistry
Endometriosis, defined as the presence of ectopic endometrial stroma and epithelium, affects approximately 10% of reproductive-age women and can cause pelvic pain and infertility. Endometriotic lesions are considered to be benign inflammatory lesions but have cancerlike features such as local invasion and resistance to apoptosis.

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