Daratumumab, Bortezomib, and Dexamethasone for Multiple Myeloma
Author(s) -
Antonio Palumbo,
Asher ChananKhan,
Katja Weisel,
Ajay K. Nooka,
Tamás Masszi,
Meral Beksaç,
Ivan Špıčka,
Vânia Hungria,
YeungChul Mun,
MaríaVictoria Mateos,
Tomer M. Mark,
Ming Qi,
Jordan M. Schecter,
Himal Amin,
Xiang Qin,
William Deraedt,
Tahamtan Ahmadi,
Andrew Spencer,
Pieter Sonneveld
Publication year - 2016
Publication title -
new england journal of medicine
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 19.889
H-Index - 1030
eISSN - 1533-4406
pISSN - 0028-4793
DOI - 10.1056/nejmoa1606038
Subject(s) - daratumumab , medicine , multiple myeloma , bortezomib , dexamethasone , hazard ratio , oncology , progression free survival , surgery , confidence interval , chemotherapy
Daratumumab, a human IgGκ monoclonal antibody that targets CD38, induces direct and indirect antimyeloma activity and has shown substantial efficacy as monotherapy in heavily pretreated patients with multiple myeloma, as well as in combination with bortezomib in patients with newly diagnosed multiple myeloma.
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