Prospective Validation of a 21-Gene Expression Assay in Breast Cancer | Zendy

Joseph A. Sparano | Zendy; Robert J. Gray | Zendy; Della Makower | Zendy; Kathleen I. Pritchard | Zendy; Kathy S. Albain | Zendy; Daniel F. Hayes | Zendy; Charles E. Geyer | Zendy; Elizabeth Claire Dees | Zendy; Edith A. Perez | Zendy; John A. Olson | Zendy; JoAnne Zujewski | Zendy; Tracy Lively | Zendy; Sunil Badve | Zendy; Thomas J. Saphner | Zendy; Lynne I. Wagner | Zendy; Timothy J. Whelan | Zendy; Matthew J. Ellis | Zendy; Soonmyung Paik | Zendy; William C. Wood | Zendy; Peter M. Ravdin | Zendy; Maccon Keane | Zendy; Henry Gómez | Zendy; Pavan S. Reddy | Zendy; Timothy F. Goggins | Zendy; Ingrid A. Mayer | Zendy; Adam Brufsky | Zendy; Deborah Toppmeyer | Zendy; Virginia Kaklamani | Zendy; James N. Atkins | Zendy; Jeffrey L. Berenberg | Zendy; George W. Sledge | Zendy

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Prospective Validation of a 21-Gene Expression Assay in Breast Cancer

Author(s) -

Joseph A. Sparano,

Robert J. Gray,

Della Makower,

Kathleen I. Pritchard,

Kathy S. Albain,

Daniel F. Hayes,

Charles E. Geyer,

Elizabeth Claire Dees,

Edith A. Perez,

John A. Olson,

JoAnne Zujewski,

Tracy Lively,

Sunil Badve,

Thomas J. Saphner,

Lynne I. Wagner,

Timothy J. Whelan,

Matthew J. Ellis,

Soonmyung Paik,

William C. Wood,

Peter M. Ravdin,

Maccon Keane,

Henry Gómez,

Pavan S. Reddy,

Timothy F. Goggins,

Ingrid A. Mayer,

Adam Brufsky,

Deborah Toppmeyer,

Virginia Kaklamani,

James N. Atkins,

Jeffrey L. Berenberg,

George W. Sledge

Publication year - 2015

Publication title -

new england journal of medicine

Language(s) - English

Resource type - Journals

eISSN - 1533-4406

pISSN - 0028-4793

DOI - 10.1056/nejmoa1510764

Subject(s) - biomarker , breast cancer , oncology , prospective cohort study , medicine , cancer , gene expression , gene , bioinformatics , biology , genetics

Prior studies with the use of a prospective-retrospective design including archival tumor samples have shown that gene-expression assays provide clinically useful prognostic information. However, a prospectively conducted study in a uniformly treated population provides the highest level of evidence supporting the clinical validity and usefulness of a biomarker.

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