A Placebo-Controlled Trial of Obeticholic Acid in Primary Biliary Cholangitis | Zendy

Frederik Nevens | Zendy; Pietro Andreoné | Zendy; G. Mazzella | Zendy; Simone I. Strasser | Zendy; Christopher L. Bowlus | Zendy; Pietro Invernizzi | Zendy; Joost P.H. Drenth | Zendy; Paul J. Pockros | Zendy; Jarosław Reguła | Zendy; Ulrich Beuers | Zendy; Michael Trauner | Zendy; David Jones | Zendy; Annarosa Floreani | Zendy; Simon Hohenester | Zendy; Velimir A. Luketic | Zendy; Mitchell L. Shiffman | Zendy; Karel J. van Erpecum | Zendy; Vı́ctor Vargas | Zendy; Catherine Vincent | Zendy; Gideon M. Hirschfield | Zendy; Hemant Shah | Zendy; Bettina E. Hansen | Zendy; Keith D. Lindor | Zendy; HannsUlrich Marschall | Zendy; Kris V. Kowdley | Zendy; Roya Hooshmand-Rad | Zendy; Tonya Marmon | Zendy; Shawn Sheeron | Zendy; Richard Pencek | Zendy; Leigh MacConell | Zendy; Mark Pruzanski | Zendy; Д. А. Шапиро | Zendy

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A Placebo-Controlled Trial of Obeticholic Acid in Primary Biliary Cholangitis

Author(s) -

Frederik Nevens,

Pietro Andreoné,

G. Mazzella,

Simone I. Strasser,

Christopher L. Bowlus,

Pietro Invernizzi,

Joost P.H. Drenth,

Paul J. Pockros,

Jarosław Reguła,

Ulrich Beuers,

Michael Trauner,

David Jones,

Annarosa Floreani,

Simon Hohenester,

Velimir A. Luketic,

Mitchell L. Shiffman,

Karel J. van Erpecum,

Vı́ctor Vargas,

Catherine Vincent,

Gideon M. Hirschfield,

Hemant Shah,

Bettina E. Hansen,

Keith D. Lindor,

HannsUlrich Marschall,

Kris V. Kowdley,

Roya Hooshmand-Rad,

Tonya Marmon,

Shawn Sheeron,

Richard Pencek,

Leigh MacConell,

Mark Pruzanski,

Д. А. Шапиро

Publication year - 2016

Publication title -

new england journal of medicine

Language(s) - English

Resource type - Journals

eISSN - 1533-4406

pISSN - 0028-4793

DOI - 10.1056/nejmoa1509840

Subject(s) - obeticholic acid , medicine , placebo , primary biliary cirrhosis , gastroenterology , clinical endpoint , bile acid , bilirubin , alkaline phosphatase , cholestasis , randomized controlled trial , agonist , pathology , biochemistry , receptor , chemistry , enzyme , alternative medicine

Primary biliary cholangitis (formerly called primary biliary cirrhosis) can progress to cirrhosis and death despite ursodiol therapy. Alkaline phosphatase and bilirubin levels correlate with the risk of liver transplantation or death. Obeticholic acid, a farnesoid X receptor agonist, has shown potential benefit in patients with this disease.

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