Open AccessIntensified Antituberculosis Therapy in Adults with Tuberculous Meningitis
Author(s) -
A Dorothee Heemskerk,
Nguyen Duc Bang,
Nguyen T.H.,
Tran Thi Hong Chau,
Nguyen Hoan Phu,
Pham Phu Loc,
Nguyễn Văn Vĩnh Châu,
Tran Tinh Hien,
Nguyen Huy Dung,
Nguyễn Thị Ngọc Lan,
Nguyễn Hữu Lân,
NgocLan Nguyen,
Le T. Phong,
Nguyen Nang Vien,
Nguyen Quang Hien,
Nguyen T.B. Yen,
Đặng Thị Minh Hà,
Jeremy Day,
Maxine Caws,
Laura Merson,
Tran Thi Van Thinh,
Marcel Wolbers,
Guy Thwaites,
Jeremy Farrar
Publication year - 2016
Publication title -
new england journal of medicine
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 19.889
H-Index - 1030
eISSN - 1533-4406
pISSN - 0028-4793
DOI - 10.1056/nejmoa1507062
Subject(s) - medicine , tuberculous meningitis , regimen , tuberculosis , hazard ratio , population , surgery , placebo , meningitis , confidence interval , environmental health , alternative medicine , pathology
Tuberculous meningitis is often lethal. Early antituberculosis treatment and adjunctive treatment with glucocorticoids improve survival, but nearly one third of patients with the condition still die. We hypothesized that intensified antituberculosis treatment would enhance the killing of intracerebral Mycobacterium tuberculosis organisms and decrease the rate of death among patients.
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