Use of a Vaginal Ring Containing Dapivirine for HIV-1 Prevention in Women | Zendy

Jared M. Baeten | Zendy; Thesla PalaneePhillips | Zendy; Elizabeth R. Brown | Zendy; Katie Schwartz | Zendy; Lydia SotoTorres | Zendy; Vaneshree Govender | Zendy; Nyaradzo Mgodi | Zendy; Flavia Matovu Kiweewa | Zendy; Gonasagrie Nair | Zendy; Felix Mhlanga | Zendy; Samantha Siva | Zendy; LindaGail Bekker | Zendy; Nitesha Jeenarain | Zendy; Zakir Gaffoor | Zendy; Francis Martinson | Zendy; Bonus Makanani | Zendy; Arendevi Pather | Zendy; Logashvari Naidoo | Zendy; Marla Husnik | Zendy; Barbra A. Richardson | Zendy; Urvi M. Parikh | Zendy; John W. Mellors | Zendy; Mark A. Marzinke | Zendy; Craig W. Hendrix | Zendy; Ariane van der Straten | Zendy; Gita Ramjee | Zendy; Zvavahera M. Chirenje | Zendy; Clemensia Nakabiito | Zendy; Taha E. Taha | Zendy; Judith Jones | Zendy; Ashley J. Mayo | Zendy; Rachel Scheckter | Zendy; Jennifer Berthiaume | Zendy; Edward Livant | Zendy; Cindy Jacobson | Zendy; Patrick Ndase | Zendy; Rhonda White | Zendy; Karen Patterson | Zendy; Donna Germuga | Zendy; Beth Galaska | Zendy; Katherine Bunge | Zendy; Devika Singh | Zendy; Daniel Szydlo | Zendy; Elizabeth Montgomery | Zendy; Barbara Mensch | Zendy; Kristine Torjesen | Zendy; Cynthia I. Grossman | Zendy; Nahida Chakhtoura | Zendy; Annaléne Nel | Zendy; Zeda Rosenberg | Zendy; Ian McGowan | Zendy; Sharon L. Hillier | Zendy

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Use of a Vaginal Ring Containing Dapivirine for HIV-1 Prevention in Women

Author(s) -

Jared M. Baeten,

Thesla PalaneePhillips,

Elizabeth R. Brown,

Katie Schwartz,

Lydia SotoTorres,

Vaneshree Govender,

Nyaradzo Mgodi,

Flavia Matovu Kiweewa,

Gonasagrie Nair,

Felix Mhlanga,

Samantha Siva,

LindaGail Bekker,

Nitesha Jeenarain,

Zakir Gaffoor,

Francis Martinson,

Bonus Makanani,

Arendevi Pather,

Logashvari Naidoo,

Marla Husnik,

Barbra A. Richardson,

Urvi M. Parikh,

John W. Mellors,

Mark A. Marzinke,

Craig W. Hendrix,

Ariane van der Straten,

Gita Ramjee,

Zvavahera M. Chirenje,

Clemensia Nakabiito,

Taha E. Taha,

Judith Jones,

Ashley J. Mayo,

Rachel Scheckter,

Jennifer Berthiaume,

Edward Livant,

Cindy Jacobson,

Patrick Ndase,

Rhonda White,

Karen Patterson,

Donna Germuga,

Beth Galaska,

Katherine Bunge,

Devika Singh,

Daniel Szydlo,

Elizabeth Montgomery,

Barbara Mensch,

Kristine Torjesen,

Cynthia I. Grossman,

Nahida Chakhtoura,

Annaléne Nel,

Zeda Rosenberg,

Ian McGowan,

Sharon L. Hillier

Publication year - 2016

Publication title -

new england journal of medicine

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 19.889

H-Index - 1030

eISSN - 1533-4406

pISSN - 0028-4793

DOI - 10.1056/nejmoa1506110

Subject(s) - medicine , incidence (geometry) , vaginal ring , placebo , confidence interval , gynecology , reverse transcriptase inhibitor , obstetrics , human immunodeficiency virus (hiv) , sida , population , immunology , viral disease , family planning , research methodology , physics , alternative medicine , environmental health , pathology , optics

Antiretroviral medications that are used as prophylaxis can prevent acquisition of human immunodeficiency virus type 1 (HIV-1) infection. However, in clinical trials among African women, the incidence of HIV-1 infection was not reduced, probably because of low adherence. Longer-acting methods of drug delivery, such as vaginal rings, may simplify use of antiretroviral medications and provide HIV-1 protection.

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