Genetic Diversity and Protective Efficacy of the RTS,S/AS01 Malaria Vaccine | Zendy

Daniel E. Neafsey | Zendy; Michal Juraska | Zendy; Trevor Bedford | Zendy; David Benkeser | Zendy; Clarissa Valim | Zendy; Allison Griggs | Zendy; Marc Lievens | Zendy; Salim Abdulla | Zendy; Samuel Adjei | Zendy; Tsiri Agbenyega | Zendy; Selidji Todagbé Agnandji | Zendy; Pedro Aíde | Zendy; Scott Anderson | Zendy; Daniel Ansong | Zendy; John J. Aponte | Zendy; Kwaku Poku Asante | Zendy; Philip Bejon | Zendy; Ashley J. Birkett | Zendy; Myriam Bruls | Zendy; Kristen M. Connolly | Zendy; Umberto D’Alessandro | Zendy; Carlota Dobaño | Zendy; Samwel Gesase | Zendy; Brian Greenwood | Zendy; Jonna Grimsby | Zendy; Halidou Tinto | Zendy; Mary J. Hamel | Zendy; Irving Hoffman | Zendy; Portia Kamthunzi | Zendy; Simon Kariuki | Zendy; Peter G. Kremsner | Zendy; Amanda Leach | Zendy; Bertrand Lell | Zendy; Niall J. Len | Zendy; John Lusingu | Zendy; Kevin Marsh | Zendy; Francis Martinson | Zendy; Jackson T. Molel | Zendy; Eli L. Moss | Zendy; Patricia Njuguna | Zendy; Christian F. Ockenhouse | Zendy; Bernhards Ogutu | Zendy; Walter Otieno | Zendy; Lucas Otieno | Zendy; Kephas Otieno | Zendy; Seth OwusuAgyei | Zendy; Daniel J. Park | Zendy; Karell G. Pellé | Zendy; Dana Robbins | Zendy; Carsten Russ | Zendy; Elizabeth M. Ryan | Zendy; Jahit Sacarlal | Zendy; Brian Sogoloff | Zendy; Hermann Sorgho | Zendy; Marcel Tanner | Zendy; Thor G. Theander | Zendy; Innocent Valéa | Zendy; Sarah K. Volkman | Zendy; Qing Yu | Zendy; Didier Lapierre | Zendy; Bruce W. Birren | Zendy; Peter B. Gilbert | Zendy; Dyann F. Wirth | Zendy

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Genetic Diversity and Protective Efficacy of the RTS,S/AS01 Malaria Vaccine

Author(s) -

Daniel E. Neafsey,

Michal Juraska,

Trevor Bedford,

David Benkeser,

Clarissa Valim,

Allison Griggs,

Marc Lievens,

Salim Abdulla,

Samuel Adjei,

Tsiri Agbenyega,

Selidji Todagbé Agnandji,

Pedro Aíde,

Scott Anderson,

Daniel Ansong,

John J. Aponte,

Kwaku Poku Asante,

Philip Bejon,

Ashley J. Birkett,

Myriam Bruls,

Kristen M. Connolly,

Umberto D’Alessandro,

Carlota Dobaño,

Samwel Gesase,

Brian Greenwood,

Jonna Grimsby,

Halidou Tinto,

Mary J. Hamel,

Irving Hoffman,

Portia Kamthunzi,

Simon Kariuki,

Peter G. Kremsner,

Amanda Leach,

Bertrand Lell,

Niall J. Len,

John Lusingu,

Kevin Marsh,

Francis Martinson,

Jackson T. Molel,

Eli L. Moss,

Patricia Njuguna,

Christian F. Ockenhouse,

Bernhards Ogutu,

Walter Otieno,

Lucas Otieno,

Kephas Otieno,

Seth OwusuAgyei,

Daniel J. Park,

Karell G. Pellé,

Dana Robbins,

Carsten Russ,

Elizabeth M. Ryan,

Jahit Sacarlal,

Brian Sogoloff,

Hermann Sorgho,

Marcel Tanner,

Thor G. Theander,

Innocent Valéa,

Sarah K. Volkman,

Qing Yu,

Didier Lapierre,

Bruce W. Birren,

Peter B. Gilbert,

Dyann F. Wirth

Publication year - 2015

Publication title -

new england journal of medicine

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 19.889

H-Index - 1030

eISSN - 1533-4406

pISSN - 0028-4793

DOI - 10.1056/nejmoa1505819

Subject(s) - circumsporozoite protein , malaria vaccine , medicine , malaria , plasmodium falciparum , vaccine efficacy , vaccination , immunology , hazard ratio , virology , genotype , confidence interval , biology , genetics , gene

The RTS,S/AS01 vaccine targets the circumsporozoite protein of Plasmodium falciparum and has partial protective efficacy against clinical and severe malaria disease in infants and children. We investigated whether the vaccine efficacy was specific to certain parasite genotypes at the circumsporozoite protein locus.

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