Vascular Effects of Early versus Late Postmenopausal Treatment with Estradiol | Zendy

Howard N. Hodis | Zendy; Wendy J. Mack | Zendy; Victor W. Henderson | Zendy; Donna Shoupe | Zendy; Matthew J. Budoff | Zendy; Juliana Hwang-Levine | Zendy; Yanjie Li | Zendy; Feng Mei | Zendy; Laurie Dustin | Zendy; Naoko Kono | Zendy; Frank Z. Stanczyk | Zendy; Robert H. Selzer | Zendy; Stanley P. Azen | Zendy

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Vascular Effects of Early versus Late Postmenopausal Treatment with Estradiol

Author(s) -

Howard N. Hodis,

Wendy J. Mack,

Victor W. Henderson,

Donna Shoupe,

Matthew J. Budoff,

Juliana Hwang-Levine,

Yanjie Li,

Feng Mei,

Laurie Dustin,

Naoko Kono,

Frank Z. Stanczyk,

Robert H. Selzer,

Stanley P. Azen

Publication year - 2016

Publication title -

new england journal of medicine

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 19.889

H-Index - 1030

eISSN - 1533-4406

pISSN - 0028-4793

DOI - 10.1056/nejmoa1505241

Subject(s) - menopause , hormone therapy , estrogen , medicine , estrogen therapy , hormone , postmenopausal women , endocrinology , disease , hormone replacement therapy (female to male) , estrogen replacement therapy , physiology , breast cancer , testosterone (patch) , cancer

Data suggest that estrogen-containing hormone therapy is associated with beneficial effects with regard to cardiovascular disease when the therapy is initiated temporally close to menopause but not when it is initiated later. However, the hypothesis that the cardiovascular effects of postmenopausal hormone therapy vary with the timing of therapy initiation (the hormone-timing hypothesis) has not been tested.

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